AIM: To investigate the effects of hydrogen (H2) on Cu, Zn superoxide dismutase (SOD1) activation in a rat model of corneal alkali burn.
METHODS: In each rat, one cornea was subjected to alkali exposure. Physiological saline (saline group) or H2-dissolved saline (H2 group) was instilled continuously on the cornea for 5min before and after alkali exposure. Inflammatory cells, neovascularization, and cytoplasmic SOD1 levels were evaluated immunohistochemically in enucleated eyes from both groups. Three-dimensional ultrastructural tissue changes in the eyes were analyzed using low-vacuum scanning electron microscopy.

Purpose: Previous work by our group has demonstrated the value of N-methyl-N-nitrosourea (MNU)-induced corneal endothelial decompensation in animal models. The aim of this study was to investigate the effect of molecular hydrogen (H2) on MNU-induced corneal endothelial cell (CEC) injury and the underlying mechanism.

Retinitis pigmentosa (RP) is a genetically heterogeneous group of inherited retinal disorders involving the progressive dysfunction of photoreceptors and the retinal pigment epithelium, for which there is currently no treatment. The rd6 mouse is a natural model of autosomal recessive retinal degeneration.

 Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice
10.1038/s41598-022-17903-8

 

Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway

https://doi.org/10.1167/iovs.62.9.2

 

132.Aoki, K., et al., Is hydrogen gas in water present as bubbles or hydrated form? Journal of Electroanalytical Chemistry, 2012. 668: p. 83-89.

133.Black, J.H., Chemistry and cosmology. Faraday Discussions, 2006. 133: p. 27-32; discussion 83-102, 449-52.

178.Ball, J., Recently published papers: More about EGDT, experimental therapies and some inconvenient truths.Critical Care, 2007. 11(5).

179.Cavallo, T., An essay on the medicinal properties of factitious airs: with an appendix on the nature of blood. 1798: Printed for the author, and sold by C. Dilly [and 2 others].